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A

[Abscess]
[Acne Conglobata]
[Acne Fulminans]
[Acne Neonatorum]
[Acne Rosacea]
[Acne, steroid]
[Acne Vulgaris]
[Actinic Keratosis]
[Actinic Prurigo]
[Actinic Purpura]
[Adenoma Sebaceum]
[Addison's Disease]
[Alopecia, androgenic]
[Alopecia Areata]
[Alopecia, stress-induced]
[Aphthous Stomatitis]
[Artecoll]
[ArteFill]
[Athlete's Foot]

B

[Basal Cell Carcinoma]
[Behcet's Disease]
[Birt-Hogg-Dubé Syndrome]
[Botox]
[Bowel-Associated Dermatosis Arthritis Syndrome]
[Bowen's Disease]
[Bullous Pemphigoid]

C

[Calcium Hydroxylapatite]
[Candidiasis, cutaneous]
[Candidiasis, oral]
[Carcinoid Syndrome]
[Cellulitis]
[Chicken Pox]
[Cicatricial Pemphigoid]
[Collagen, bovine]
[Colloid Millium]
[Corn]
[Cryotherapy]
[Cutis Rhomboidalis Nuchae]
[Cymetra]
[Cyst]

D

[Dermal Fillers]
[Dermalogen]
[Dermatitis]
[Dermatitis, atopic]
[Dermatitis, contact]
[Dermatitis, nonspecific]
[Dermatitis, seborrheic]
[Dermatitis, stasis]
[Dermatitis Herpetiformis]
[Dermatofibroma]
[Dermatofibrosarcome Protuberans]
[Discoid Lupus Erythematosus]
[Disseminated Intravascular Coagulation]
[Drug Eruptions (Rash)]

E

[Eczema]
[Epidermal Inclusion Cyst]
[Ehler's-Danlos Syndrome]
[Epidermolysis Bullosa]
[Erythema Migrans]
[Erythema Multiforme]
[Erythema Nodosum]
[Erythroplasia of Queyrat]
[Exanthem, viral]

F

[Fascian]
[Favre-Racouchot Syndrome]
[Freckle]
[Folliculitis]
[Fungal Culture]
[Fungal Infections]
[Furuncle]

G

[Gestational Pemphigoid]
[Glomus Tumor]
[Granuloma Faciale]
[Granuloma Inguinale]

H

[Hair Loss]
[Hand, Foot, and Mouth Disease]
[Hemangioma]
[Herpangina]
[Herpes Simplex Virus]
[Herpes Zoster]
[Hives]
[Hidradenitis Suppurativa]
[Human Herpes Virus 8 (HHV-8)]
[Hyaluronic Acid]
[Hylaform]
[Hyperhidrosis]
[Hyperpigmentation]
[Hypopigmentation, postinflammatory]

I

[Impetigo]
[Impetigo, bullous]
[Incontinentia Pigmenti]
[Infantile Acropustulosis]
[Insect bite or sting]
[Intense Pulse Light]

J

[Juvéderm]

K

[Kaposi's Sarcoma]
[Keloid]
[Keratoacanthoma]
[Keratosis Pilaris]

L

[Laser]
[Laser, CO2]
[Laser, diode]
[Laser, Er:YAG, pulsed]
[Laser, excimer]
[Laser, Nd:YAG, pulsed]
[Laser, Nd:YAG, Q-switched]
[Laser, pulsed dye]
[Laser Hair Removal]
[Lentigo]
[Leukoplakia, oral]
[Lichen Planus]
[Lichen Simplex Chronicus]
[Linear IgA Bullous Disease]
[Lipoma]
[Lupus Erythematosus, discoid]
[Lupus Erythematosus, systemic]

M

[Melanoma]
[Melasma]
[Mesolis]
[Milia]
[Miliaria]
[Moh's Surgery]
[Molluscum Contagiosum]
[Morphea]
[Mucous Membrane Pemphigoid]
[Muir-Torre Syndrome]
[Mycosis Fungoides]
 

N

[Neonatal Acne]
[Neonatal Cephalic Pustulosis]
[Neurofibroma]
[Nevus]
[Nevus, dysplastic]
[New-Fill]
[Notalgia Paresthetica]

O

[Ochronosis]
[Onychomycosis]
[Oral Ulcer]

P

[Pachyonychia Congenita]
[Paget's Disease]
[Paronychia]
[Pemphigus Vulgaris]
[Photoaging]
[Photodermatoses]
[Photodynamic Therapy]
[Pityriasis Alba]
[Pityriasis Lichenoides et Varioliformis Acuta (PLEVA)]
[Pityriasis Lichenoides Chronica (PLC)]
[Pityriasis Rosea]
[Poikiloderma of Civatte]
[Polymorphous Light Eruption]
[Porokeratosis]
[Porphyria Cutanea Tarda]
[Postinflammatory Hyperpigementation]
[Postinflammatory Hypopigmentation]
[Psoralen + UVA (PUVA)]
[Psoriasis]
[Purpura]
[Purpura, actinic]
[Purpura, thrombocytopenic]
[PUVA]
[Pyoderma Gangrenosum]

R

[Radiesse]
[Relapsing Polychondritis]
[Restylane]
[Rhinophyma]
[Rosacea]

S

[SAPHO Syndrome]
[Sarcoidosis]
[Scabies]
[Schamberg's Disease]
[Schnitzler Syndrome]
[Scleroderma]
[Sculptra]
[Sebaceous Hyperplasia]
[Seborrheic Keratosis]
[Shingles]
[Skin Tag]
[Sneddon-Wilkinson Disease]
[Solar Elastosis]
[Squamous Cell Carcinoma]
[Steatocystoma]
[Stevens-Johnson Syndrome]
[Stewart-Treves Syndrome]
[Sweet's Syndrome]
[Syphilis, primary]
[Syphilis, secondary]
[Systemic Lupus Erythematosus (SLE)]

T

[Thrush]
[Tinea]
[Tinea Capitis]
[Tinea Corporis]
[Tinea Cruris]
[Tinea Faciale]
[Tinea Imbricata]
[Tinea Manuum]
[Tinea Pedis]
[Tinea Unguium]
[Tinea Versicolor]
[Thermage]
[Toxic Erythema]
[Trichotillomania]
[Tuberous Sclerosis]

U

[Ulcer, oral]
[Ulcer, skin]
[Urticaria]

V

[Varicella]
[Vasculitis]
[Viral Exanthem]
[Vitiligo]

W

[Wart]
[Wiskott-Aldrich Syndrome]

X

[Xanthoma]

Z

[Zyderm I]
[Zyderm II]
[Zyplast]
 

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Dermatofibrosarcoma Protuberans

What is dermatofibrosarcoma protuberans?

Dermatofibrosarcoma protuberans (DFSP) is a slow growing tumor, usually found on the trunk and proximal extremities of young to middle-aged adults.  Although it rarely metastasizes it can be locally aggressive.  It has a high rate of recurrence. The tumors can be solitary or multiple nodules, erythematous to skin colored, and ranging from 0.5 cm to more than 10 cm.

Most cases of DFSP are associated with a specific chromosomal reciprocal translocation, t(17;22)(q22;q13).  This results in the fusion of two genes: collagen type 1 (COL1A1) and platelet derived growth factor (PDGF).

With what can dermatofibrosarcoma protuberans be confused?

Clinically, DFSP can resemble a keloid or a dermatofibroma.

How is dermatofibrosarcoma protuberans diagnosed?

DFSP is diagnosed by biopsy.  On histopathology, DFSP is a dermal tumor, usually extending into the subcuticular fat. It has interwoven bundles of spindle cells in a storiform pattern. Atypical cells are only rarely obseved.  On immunohistochemistry, DFSP stains CD34 positive and usually factor XIIIa negative, distinguishing it from a dermatofibroma.

How is dermatofibrosarcoma protuberans treated?

Surgical excision is required.

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What is the prognosis for dermatofibrosarcoma protuberans?

DFSP has a high rate of local recurrence, even after surgery.  The recurrence rate may be reduced with the use of Moh's micrographic surgery. DFSP rarely metastasizes.

Date created 04/01/2008

Last updated 01/03/2009