A B
C D
E F
G
H I
J K L
M N
O
P Q
R
S T
U
V
W X Y
Z
[Home]
[Dermatology
News]
[Dermatology
Drug Guide]
[Read or Post to
Bulletin Board]
A
[Abscess]
[Acne Conglobata]
[Acne Fulminans]
[Acne Neonatorum]
[Acne Rosacea]
[Acne, steroid]
[Acne Vulgaris]
[Actinic Keratosis]
[Actinic Prurigo]
[Actinic Purpura]
[Adenoma Sebaceum]
[Addison's Disease]
[Alopecia, androgenic]
[Alopecia Areata]
[Alopecia, stress-induced]
[Aphthous Stomatitis]
[Artecoll]
[ArteFill]
[Athlete's Foot]
B
[Basal Cell Carcinoma]
[Behcet's Disease]
[Birt-Hogg-Dubé Syndrome]
[Botox]
[Bowel-Associated
Dermatosis Arthritis Syndrome]
[Bowen's Disease]
[Bullous Pemphigoid]
C
[Calcium Hydroxylapatite]
[Candidiasis, cutaneous]
[Candidiasis, oral]
[Carcinoid Syndrome]
[Cellulitis]
[Chicken Pox]
[Cicatricial Pemphigoid]
[Collagen, bovine]
[Colloid Millium]
[Corn]
[Cryotherapy]
[Cutis
Rhomboidalis Nuchae]
[Cymetra]
[Cyst]
D
[Dermal Fillers]
[Dermalogen]
[Dermatitis]
[Dermatitis, atopic]
[Dermatitis, contact]
[Dermatitis, nonspecific]
[Dermatitis, seborrheic]
[Dermatitis, stasis]
[Dermatitis Herpetiformis]
[Dermatofibroma]
[Dermatofibrosarcome Protuberans]
[Discoid Lupus Erythematosus]
[Disseminated Intravascular
Coagulation]
[Drug Eruptions (Rash)]
E
[Eczema]
[Epidermal Inclusion Cyst]
[Ehler's-Danlos Syndrome]
[Epidermolysis Bullosa]
[Erythema Migrans]
[Erythema Multiforme]
[Erythema Nodosum]
[Erythroplasia of Queyrat]
[Exanthem, viral]
F
[Fascian]
[Favre-Racouchot Syndrome]
[Freckle]
[Folliculitis]
[Fungal Culture]
[Fungal Infections]
[Furuncle]
G
[Gestational Pemphigoid]
[Glomus Tumor]
[Granuloma Faciale]
[Granuloma Inguinale]
H
[Hair Loss]
[Hand, Foot, and Mouth Disease]
[Hemangioma]
[Herpangina]
[Herpes Simplex Virus]
[Herpes Zoster]
[Hives]
[Hidradenitis Suppurativa]
[Human Herpes Virus 8 (HHV-8)]
[Hyaluronic Acid]
[Hylaform]
[Hyperhidrosis]
[Hyperpigmentation]
[Hypopigmentation,
postinflammatory]
I
[Impetigo]
[Impetigo, bullous]
[Incontinentia Pigmenti]
[Infantile Acropustulosis]
[Insect bite or sting]
[Intense Pulse Light]
J
[Juvéderm]
K
[Kaposi's Sarcoma]
[Keloid]
[Keratoacanthoma]
[Keratosis Pilaris]
L
[Laser]
[Laser, CO2]
[Laser, diode]
[Laser, Er:YAG, pulsed]
[Laser, excimer]
[Laser, Nd:YAG, pulsed]
[Laser, Nd:YAG, Q-switched]
[Laser, pulsed dye]
[Laser Hair Removal]
[Lentigo]
[Leukoplakia, oral]
[Lichen Planus]
[Lichen Simplex Chronicus]
[Linear IgA Bullous Disease]
[Lipoma]
[Lupus Erythematosus, discoid]
[Lupus Erythematosus, systemic]
M
[Melanoma]
[Melasma]
[Mesolis]
[Milia]
[Miliaria]
[Moh's Surgery]
[Molluscum Contagiosum]
[Morphea]
[Mucous Membrane Pemphigoid]
[Muir-Torre Syndrome]
[Mycosis Fungoides]
N
[Neonatal Acne]
[Neonatal Cephalic Pustulosis]
[Neurofibroma]
[Nevus]
[Nevus, dysplastic]
[New-Fill]
[Notalgia Paresthetica]
O
[Ochronosis]
[Onychomycosis]
[Oral Ulcer]
P
[Pachyonychia Congenita]
[Paget's Disease]
[Paronychia]
[Pemphigus Vulgaris]
[Photoaging]
[Photodermatoses]
[Photodynamic Therapy]
[Pityriasis Alba]
[Pityriasis Lichenoides et Varioliformis
Acuta (PLEVA)]
[Pityriasis Lichenoides Chronica (PLC)]
[Pityriasis Rosea]
[Poikiloderma of Civatte]
[Polymorphous Light Eruption]
[Porokeratosis]
[Porphyria Cutanea Tarda]
[Postinflammatory
Hyperpigementation]
[Postinflammatory
Hypopigmentation]
[Psoralen + UVA (PUVA)]
[Psoriasis]
[Purpura]
[Purpura, actinic]
[Purpura, thrombocytopenic]
[PUVA]
[Pyoderma Gangrenosum]
R
[Radiesse]
[Relapsing Polychondritis]
[Restylane]
[Rhinophyma]
[Rosacea]
S
[SAPHO Syndrome]
[Sarcoidosis]
[Scabies]
[Schamberg's Disease]
[Schnitzler Syndrome]
[Scleroderma]
[Sculptra]
[Sebaceous Hyperplasia]
[Seborrheic Keratosis]
[Shingles]
[Skin Tag]
[Sneddon-Wilkinson Disease]
[Solar Elastosis]
[Squamous Cell Carcinoma]
[Steatocystoma]
[Stevens-Johnson Syndrome]
[Stewart-Treves Syndrome]
[Sweet's Syndrome]
[Syphilis, primary]
[Syphilis, secondary]
[Systemic Lupus Erythematosus (SLE)]
T
[Thrush]
[Tinea]
[Tinea Capitis]
[Tinea Corporis]
[Tinea Cruris]
[Tinea Faciale]
[Tinea Imbricata]
[Tinea Manuum]
[Tinea Pedis]
[Tinea Unguium]
[Tinea Versicolor]
[Thermage]
[Toxic Erythema]
[Trichotillomania]
[Tuberous Sclerosis]
U
[Ulcer, oral]
[Ulcer, skin]
[Urticaria]
V
[Varicella]
[Vasculitis]
[Viral Exanthem]
[Vitiligo]
W
[Wart]
[Wiskott-Aldrich Syndrome]
X
[Xanthoma]
Z
[Zyderm I]
[Zyderm II]
[Zyplast]
A B
C D
E F
G
H I
J K L
M N
O
P Q
R
S T
U
V
W X Y
Z
[Home]
|
Discoid Lupus Erythematosus
What is discoid lupus erythematosus (DLE)?
Discoid lupus erythematosus is a skin rash that can occur in
lupus; it may be limited to the skin or be a sign of systemic lupus
erythematosus (SLE). It consists of reddish purple discoid plaques with white
scale. The scale can sometimes be removed in one piece, and the underside may
exhibit "carpet tacks", small spikes that indicate where the scale plugged a
hair follicle. Lesions may worsen after exposure to sunlight. As lesions mature
they appear as depressed atrophic plaques, often with central hypopigmentation
and a hyperpigmented rim. The rash is usually asymptomatic, but may be
slightly pruritic. Mucosal erosions may also occur.
What is the association between hair loss and discoid lupus erythematosus?
Oval patches of scarring alopecia (hair
loss) sometimes occur with DLE. The center of the lesion is typically white
and atrophic, while the rim is erythematous. As is the case for skin lesions of
discoid lupus erythematosus, keratin-plugged follicles are present.
Telangiectasias may be found as well.
With what can discoid lupus erythematosus be confused?
DLE is most often confused with
psoriasis. Also in the differential is lichen
planus. The focal scarring alopecia of discoid lupus erythematosus
has a relatively narrow differntial diagnosis, including
tinea capitis
and lichen planus.
How is discoid lupus erythematosus diagnosed?
Diagnosis requires a skin biopsy. The lupus band test is
positive (i.e. direct immunofluorescence), with immunoglobulins deposited at the
dermal-epidermal junction in involved skin.
A complete history should be taken to elicit symptoms of
systemic lupus erythematosus, such as photosensitivity, hair loss, oral
ulceration, Raynaud's phenomenon, and arthritis. Laboratory evaluation for
SLE should be performed, including anti-nuclear antibody (ANA) and confirmatory
anti-DNA antibody tests, complete blood count, and urinalysis.
See:
Pathology: Discoid Lupus Erythematosus
How is discoid lupus erythematosus treated?
The lesions usually respond to topical or intralesional
steroids. Sun protection with broad spectrum sunscreens and sun avoidance is
important. Resistant or extensive lesions require systemic therapy, which may
include the antimalarial drugs chloroquine and hydroxychloroquine. Alternatives
are retinoids, dapsone, and gold compounds. In the case of
hair loss, early treatment is directed at preventing
eradication of the follicle and irreversible allopecia.
What is the prognosis for discoid lupus erythematosus?
DLE is a chronic but usually manageable disease, with new
lesions appearing as others resolve. Remission occurs in up to 50% of
patients. Scarring, postinflammatory hypo- and hyper-pigmentation, and scarring
alopecia can occur, which can be permanent. The risk of developing SLE is 5-10% in patients that lack
other symptoms of SLE at the time of presentation.
|
Image links
|
Other useful links
|
Date created 04/14/2007
Last updated
01/03/2009
|